The 3-star Domatio Melissa Hotel Sassari provides proximity to the G.A. Sanna National Museum, which is situated 16 minutes' walk away. Wi-Fi is offered in public areas at the guest house.

Located only 450 metres from the Sassari Ducal Palace, this pet-friendly hotel also provides easy access to the Roman Catholic Sassari Cathedral. Approximately a 25-minute walk from the property, guests will find the Monserrato Park. There is the neoclassical Palazzo Giordano a mere 1.1 km away, and Via Tavolara bus station is right around the corner from the Domatio Melissa. For those travelling from afar, Fertilia airport is 28 minutes' drive away.

The rooms at this Sassari hotel include an iron and air conditioning, as well as media facilities like a flat-screen TV with satellite channels. They are furnished with sound-proofed windows, and also come with tea/coffee making equipment. Guests will make use of bathrobes and towels in bathrooms equipped with a separate toilet and a shower.

Located just 550 m from Domatio Melissa Hotel, the restaurant Il Vecchio Mulino offers a Sardinian menu.